“represent about 70 percent of your muscle mass” (Glycemic Load Diet p.78). So activating them is key.
Squats are good, Deadlifts are good, Leg curls are good, Leg Extensions are good, Hack squats are good, and the list goes on.
However, don’t forget to hit the pavement after your workout. Those Glycogen stores will be depleted and your body will be forced to burn fat for energy. Get to walking.